PhD student (f/m/x) in Translational Protein Biochemistry

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The DZNE group Translational Protein Biochemistry (Prof. Dr. T.M Böckers) is offering 1 PhD position with focus on the molecular and synaptic pathomechanisms affecting neurons in neurological conditions especially neurodegenerative diseases (e.g., amyotrophic lateral sclerosis and frontotemporal dementia) and traumatic brain injury leading to neurodegeneration. In particular, the focus of this position will be to test novel modulators of synaptic activity to achieve neuroprotection. Our international research team is embedded in a collaboration between the DZNE group Translational Protein Biochemistry and the Institute for Anatomy and Cell Biology and in two Collaborative Research Centres at the University of Ulm (SFB1149; SFB1506) and receives funding from prestigious national and international organizations (such as DFG, BMBF, Else Kröner-Fresenius-Stiftung, Frick Foundation). By working in close collaboration with the Clinic of Neurology, we prioritize investigations aimed at a better understanding of pathological conditions, as well as the development of novel therapeutic strategies that might be transferred to patients. Our lab has long experience in the investigation of the physiological and pathologic mechanisms characterizing the neuron, and especially the synapse, by using a collection of murine models (Shanks-deficient) and a unique library of human iPSC lines (from PMDS, ALS, SMA, FTD and Alzheimer´s disease patients) that we differentiate into neuronal and glial cells, as well as cerebral and spinal organoids. The lab is equipped with a state-of-the-art setup including confocal, light sheet and STED microscopes, MEA devices and dedicated cell culture rooms for hiPSC-based models.

Successful applicants can obtain their doctoral degree by joining the International Graduate School in Molecular Medicine.

• Active participation in experimental work, experimental design, data generation, data analyses, and interpretation of results
• Prepare and write manuscripts for publication in international scientific journals
• Oral presentation of results on local, national, and international conferences
• Experimental work includes molecular biology, especially cell culture of induced pluripotent stem cells

• A keen interest in molecular biology and working with induced pluripotent stem cells
• Experience in molecular biology and handling of pluripotent stem cells is advantageous
• A master’s degree in molecular biology, neuroscience, biochemistry (or a master’s degree in a related field)
• Fluency in English

• Innovation und Internationalität:

  Durch zukunftsweisende Infrastruktur, moderne Labor- und Büroausstattung, Softwaretools und die Chance zum internationalen Austausch mit Menschen aus 65 Nationen

• Individuelle Einarbeitung:

  Für einen guten Einstieg in Ihre neue berufliche Herausforderung

• Gesundheitsförderung:

  Unser umfangreiches Angebot an betrieblichen Gesundheitsmaßnahmen, in Zusammenarbeit mit dem Sozialwerk.Bund

• Arbeitsumgebung zum Wohlfühlen:

  Unsere Bonner Mitarbeitenden erfreuen sich über einen Campus mitten im Grünen, mit Parkmöglichkeiten und ÖPNV-Anbindung vor Ort sowie einem attraktiven Kantinenangebot

• Entwicklung im Fokus:

  Individuell auf Sie abgestimmte Fortbildungsangebote und jährliche Personalentwicklungsgespräche für konkrete Perspektiven und Potenzialentfaltung

• Familienbewusste Unternehmenskultur:

  Weil wir wissen, dass Familie wichtig ist, unterstützen wir mit unserem Familienservice

• Work Life Balance:

  Wir bringen Beruf und Privatleben in Einklang mit flexiblen Arbeitszeiten, 30 Tagen Urlaub (zusätzlich frei an Heiligabend und Silvester) sowie bezuschussten Job-/Deutschlandticketoptionen