PhD student (f/m/x) in Systems Aging

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• A Master's degree (or equivalent) in biomedical sciences, neuroscience, biology, bioinformatics, or a related discipline
• Strong analytical skills and an interest in statistical and data-driven research approaches
• The ability to work independently while contributing effectively to an interdisciplinary and international team
• Good communication skills in English, both written and spoken

Your role in cutting edge research

The group of Dr. Daniele Bano investigates how cellular systems maintain resilience and adapt to environmental challenges, with a particular focus on the interplay between chromatin regulation, metabolism, and organismal longevity. Using model organisms and human cellular systems, a major theme of their research is the integration of epigenetic mechanisms with mitochondrial biology, revealing how changes in metabolic state and organelle function shape cellular identity, inflammatory responses, and survival. By combining genetic, biochemical, multi-omics, and cellular approaches, this research provides insights into fundamental mechanisms of biological resilience and highlights potential strategies for understanding and mitigating mitochondrial and age-related disorders.

The group of Dr. Dan Ehninger focuses on understanding the molecular, physiological, and systemic mechanisms underlying biological aging and age-related decline. Using large-scale multi-omics approaches and comprehensive phenotyping in mouse models, their work investigates how aging unfolds across organs and biological systems, revealing tissue-specific and shared trajectories of transcriptomic and proteomic changes. Their research has identified key aging signatures linked to immune regulation, mitochondrial dysfunction, cellular senescence, metabolism, and extracellular matrix remodeling. Beyond molecular profiling, they examine how interventions such as dietary modulation and putative anti-aging strategies influence functional outcomes, including reproductive behavior and age-associated phenotypes. A central theme of their work is the development of improved frameworks to distinguish effects on lifespan from genuine modulation of aging processes, emphasizing multidimensional approaches for evaluating aging mechanisms. 

• Innovation und Internationalität:

  Durch zukunftsweisende Infrastruktur, moderne Labor- und Büroausstattung, Softwaretools und die Chance zum internationalen Austausch mit Menschen aus 65 Nationen

• Entwicklung im Fokus:

  Individuell auf Sie abgestimmte Fortbildungsangebote und jährliche Personalentwicklungsgespräche für konkrete Perspektiven und Potenzialentfaltung

• Work Life Balance:

  Wir bringen Beruf und Privatleben in Einklang mit flexiblen Arbeitszeiten, 30 Tagen Urlaub (zusätzlich frei an Heiligabend und Silvester) sowie bezuschussten Job-/Deutschlandticketoptionen

• Gesundheitsförderung:

  Unser umfangreiches Angebot an betrieblichen Gesundheitsmaßnahmen, in Zusammenarbeit mit dem Sozialwerk.Bund

• Familienbewusste Unternehmenskultur:

  Weil wir wissen, dass Familie wichtig ist, unterstützen wir mit unserem Familienservice

• Arbeitsumgebung zum Wohlfühlen:

  Unsere Bonner Mitarbeitenden erfreuen sich über einen Campus mitten im Grünen, mit Parkmöglichkeiten und ÖPNV-Anbindung vor Ort sowie einem attraktiven Kantinenangebot