The German Center for Neurodegenerative Diseases (DZNE) is a world-leading internationally oriented research center, committed to discovering new approaches to prevent and treat neurodegenerative diseases. To this end, researchers at ten DZNE sites across Germany pursue a translational and interdisciplinary strategy comprising five interconnected areas: fundamental research, clinical research, health care research, population health science, and systems medicine. www.dzne.de

Postdoctoral Researcher (f/m/x)

Code: 1073/2022/4

We are interested in disorders associated with mitochondrial dysfunction, including metabolic syndromes and neurodegenerative diseases. Our work aims to investigate molecular mechanisms contributing to the “phenotypic threshold effect” of mitochondrial dysfunction.  Using Caenorhabditis elegans as an in vivo model, we demonstrated the importance of chromatin remodeling (Piazzesi A. et al, 2016; Piazzesi A. et al, 2022) and metabolic rewiring (Piazzesi A. et al, 2022; Jackson J. et al, 2022) in the survival of animals carrying mitochondrial lesions. From our recently performed multi-omics and epistatic analyses, we will expand our work and explore signaling cascades that can convert “short-lived’ mitochondrial mutants in “long-lived” ones. As an additional effort, we will scale-up our investigation and test candidate processes in mitochondrial mutant iPSC-derived neurons.


Your tasks

The groundwork of this project builds on our previous cross-species studies (Meyer K. et al, 2015; Piazzesi A. et al, 2016; Wischhof L. et al, 2017; Wischhof L. et al, 2018; Gioran A. et al, 2019; Bertan F. et al, 2021; Piazzesi A. et al, 2022; Wischhof L. et al, 2022; Jackson J. et al, 2022; Wischhof L. et al, under revision). Apart from C. elegans, our laboratory employs additional in vitro and in vivo models (e.g., transgenic mice and human iPSCs) and state-of-the-art instruments of which the successful candidates will be able to take full advantage.

Requirements

We are searching for a team player fully committed to the advertised project. Previous experience with C. elegans and/or iPSCs is considered a plus.

The project will develop over the initial 12-months-contract, with the concrete possibility to extend the postdoctoral experience for additional 2 years. Employees will acquire skills and knowledge for their scientific qualifications during their activities at the DZNE.

Our Institute offers

  • An international environment characterized by a strong focus on science and research;
  • A high potential for targeted personnel development;
  • Employment, payment and social benefits are determined by the Public Sector Collective Agreement (Tarifvertrag für den öffentlichen Dienst – TVöD Bund).
Apply here

Site

Bonn

Contact details

Dr. Daniele Bano

Working hours

full-time

Contract length

1 year, extension possible

Payment, social benefits

according to TVöD Bund

Application deadline

July 1st, 2022

The DZNE is an equal opportunity employer. It is committed to employing disabled individuals and especially encourages them to apply. We would like to point out that as an employee (m/f/x) of the DZNE Bonn you are subject to facility-related compulsory vaccination against the COVID-19 virus (according to § 20a of the Infection Protection Act).