The German Center for Neurodegenerative Diseases (DZNE) is a world-leading internationally oriented research center, committed to discovering new approaches to prevent and treat neurodegenerative diseases. To this end, researchers at ten DZNE sites across Germany pursue a translational and interdisciplinary strategy comprising five interconnected areas: fundamental research, clinical research, health care research, population health science, and systems medicine. www.dzne.de

PhD student (f/m/x)

Code: 1078/2022/5

Job location: Cologne, Germany

The ENP lab has state-of-the-art equipment and a motivated team of experts in molecular biology, rodent behavior, and electrophysiology of the hippocampus and cortex. In the framework of our project in the DFG Research Unit Epileptogenesis of genetic epilepsies (FOR 2715), we investigate the molecular, structural, and functional changes underlying epileptogenesis in ion channelopathies.

We invite applicants interested in studying the neural basis of learning and memory, cortical development, and the evolution of disease processes centered on ion channelopathies.


Your tasks

Generate and analyze electrophysiological, optogenetic, and behavioral experiments in mouse models of developmental and epileptic encephalopathies (DEEs). Candidates with exceptional computational skills will have the opportunity to shift the balance of their research towards design and analysis if desired.

Requirements

Candidates should hold an M.Sc. degree or equivalent, preferably in neuroscience, biomedical engineering, or a related field. Students of physics, statistics, or engineering with previous experience in neuroscience are encouraged to apply.

Strong programming skills (>1 year of programming experience in, e.g., Matlab, Python, C++); experience in spectral and time series analysis; understanding linear algebra and dimensionality reduction are prerequisites.

Excellent written and oral English communication skills are required.

Applicants are encouraged to review Peters et al., 2005 (http://dx.doi.org/10.1038/nn1375), Marguet et al., 2015 (http://dx.doi.org/10.1038/nm.3987), Meier et al., 2020 (https://doi.org/10.1523/JNEUROSCI.2275-19.2020), Graf et al., 2021 (https://doi.org/10.1073/pnas.2014784118), Merseburg, et al., 2021 (https://doi.org/10.1101/2021.08.16.456452).

 

Apply now

Site

Bonn

Contact details

Prof. Isbrandt

Working hours

full-time

Contract length

fixed-term

Payment, social benefits

according to TVöD Bund

Application deadline

May26th, 2022

The DZNE is an equal opportunity employer. It is committed to employing disabled individuals and especially encourages them to apply. You will obtain special skills and knowledge for your scientific qualification during your activities at DZNE