The German Center for Neurodegenerative Diseases (DZNE) is a unique non-university research center which is dedicated to the subject dementia and all its areas, as well as other neurodegenerative diseases. The center compasses the full spectrum of fundamental research through population sciences to health care research. The DZNE stands for excellence in research and science management, translation of scientific results into practice, interdisciplinarity and internationalization. It is a research center within the Helmholtz Organization of German research centers. With over 1000 employees from 55 nations, spread over 10 sites, the DZNE is one of the national and international leading research centers in its research field. 

PhD student (f/m) – Neurogenesis-inspired computational modeling for neurotherapies

Code: 8014/2018/9

The laboratory of plasticity models for aging and neurodegeneration (PMAN) offers an opportunity for a PhD position for an outstanding candidate to build up a neurogenic plasticity computational model to envision prospective therapies of neurodegenerative disorders. The major objective of our lab is to examine groundbreaking questions on the functional and molecular role of newly-generated neurons in the adult brain. Using a variety of modern techniques (molecular and cellular biology, electrophysiology, genetics, opto-/chemogenetics, modeling, and neurocomputation); the aim is to link experimental neuroscience to computational modeling to provide an explicit bidirectional prediction for complex performance and network neurogenic reserve for functional compensation to the brain demands in health and disease.

We are building a truly interdisciplinary research unit where experimental neuroscience, theory, and engineering expertise team up to foster advances in neuroscience and neurotherapies. Join us and be one of the first ones to better understand the brain function using cutting-edge neurotech to improve the use of newly-generated neurons in the brain to stall aging and neurodegeneration. For more information on our research, check PMAN lab page (www.dzne.de/amin/)


Your tasks

This PhD position is aimed to perform multimodal multi-level experimental readouts (molecular, cellular, and network) to implement an integrative comprehensive bottom-up neurogenic network model for neuronal reserve therapies of a specific neurodegenerative disorder. These experiments will use a combination of approaches including in vitro and ex vivo electrophysiology and imaging in human-derived neurons and transgenic mice. The successful candidate will take part in all aspects of the project, from experimental design, data generation, modeling and analyses, interpretation and writing of the manuscript.

Requirements

The PMAN lab is looking for an enthusiastic, talented, creative, team-player fluent in English with a strong commitment to research. The candidate should preferably have a master degree in neurocomputation, neuroscience, computer science, and biomedical engineering or related disciplines.

The successful candidate will implement a neurocomputational model and complex statistical analyses based on large-scale neuronal electrical activity and live cell imaging. The candidate will also carry out experiments by exploiting various tools: cell culture / Immunostaining and advance microscopy (confocal and calcium imaging) / in vitro and ex vivo Electrophysiology (multielectrode arrays and patch clamp recordings). Therefore, a robust previous coursework and experience in programming (Matlab and Python), theoretical and practical background in modeling, biostatistics, and complex data analysis methods are required. Additionally, a previous experience or an affinity for experimental neuroscience and electrophysiology is an advantage, but not necessarily required.

We offer

  • Advanced interdisciplinary vocational training
  • Opportunity to learn cutting-edge neuroscience and neurotechniques in a competitive and instructive environment
  • Excellent infrastructure including modern workspaces
  • Dynamic and multicultural environment
  • Employment, payment and social benefits are consistent with those at other research institutes

 

Site

Dresden

Contact details

Dr Hayder Amin

Working hours

full-time

Contract length

2 years

Payment, social benefits

consistent with those at other research institutes

Application deadline

Review of applications will begin immediately and continue until the position is filled.

You will obtain special skills and knowledge for your scientific qualification at DZNE. The DZNE is an equal opportunity employer. It is committed to employing disabled individuals and especially encourages them to apply.