The German Center for Neurodegenerative Diseases (DZNE) is a unique non-university research center which is dedicated to the subject dementia and all its areas, as well as other neurodegenerative diseases. The center compasses the full spectrum of fundamental research through population sciences to health care research. The DZNE stands for excellence in research and science management, translation of scientific results into practice, interdisciplinarity and internationalization. It is a research center within the Helmholtz Organization of German research centers. With over 1000 employees from 55 nations, spread over 10 sites, the DZNE is one of the national and international leading research centers in its research field.
PhD student (f/m)
The group of Dr. Daniele Bano studies the interplay between epigenetic plasticity, mitochondrial function and metabolism in aging and neurodegenerative diseases. We have studied molecular regulators of mitochondrial activity that influence cellular physiology and animal survival (Gioran A. et al, 2014; Meyer K. et al, 2015; Troulinaki K. et al, 2018; Wischhof L. et al, 2018; Gioran A. et al, under revision). In collaboration with other research groups, we have elucidated novel mitochondria-dependent molecular cascades that control metabolic and degenerative processes (Sendoel A. et al, 2014; Sellin J. et al, 2018; Arnoux I. et al, 2018). In invertebrates as well as in higher organisms, we have investigated epigenetic factors that promote longevity and neuronal maintenance (Piazzesi A. et al, 2016; Wischhof L. et al, 2017). Next, we wish to focus on molecular mechanisms that contribute to alpha-synuclein pathology in the context of diseases associated with mitochondrial dysfunction.
As part of the project, we will perform screenings of candidate genes that may modulate alpha-synuclein homeostasis (e.g., degradation, synthesis, posttranslational modifications), aggregation and spreading. The work is based on the use of the nematode Caenorhabditis elegans and, later, on transgenic mouse models. As part of a European network, our work will benefit from world-leading experts in the field of Parkinson’s disease. The project encompasses a variety of technologies, including confocal microscopy, histochemical approaches, biochemistry and cellular biology (e.g., primary cells, CRISPR/Cas9-modified iPSC).
We are looking for a highly motivated and science-driven person with a recent M.sc. degree or equivalent qualification; a background in neuroscience or related areas of biology (e.g., neurobiology, molecular biology, (epi)-genetics); solid hands-on experience in laboratory animal experimentation; knowledge of common methods in molecular and cell biology. Previous experience in the following areas would be considered a plus: C. elegans, tissue preparation and immunohistochemistry; confocal microscopy and imaging analysis; iPSC work. The successful candidate has good communication skills and is a team player.
- An exciting and fully funded research project
- Committed mentorship
- An excellent scientific environment in a major center for translational neuroscience research
- Access to state-of-the-art equipment and facilities
- Targeted career development
Dr. Daniele Bano
Payment, social benefits
consistent with those at other research institutes
December 15th, 2018
You will obtain special skills and knowledge for your scientific qualification during your activities at DZNE. The DZNE is an equal opportunity employer. It is committed to employing disabled individuals and especially encourages them to apply.