The German Center for Neurodegenerative Diseases (DZNE) is a unique non-university research center which is dedicated to the subject dementia and all its areas, as well as other neurodegenerative diseases. The center compasses the full spectrum of fundamental research through population sciences to health care research. The DZNE stands for excellence in research and science management, translation of scientific results into practice, interdisciplinarity and internationalization. It is a research center within the Helmholtz Organization of German research centers. With over 1000 employees from 55 nations, spread over 10 sites, the DZNE is one of the national and international leading research centers in its research field. 

Postdoctoral Researcher (f/m/d) in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis Research

Code: 3044/2018/11

The main goal of the research group “Molecular Neuropathology of Neurodegenerative Diseases” (Prof. Dr. Manuela Neumann) is to understand the molecular mechanisms underlying frontotemporal dementia and amyotrophic lateral sclerosis, with specific emphasis on the role of TDP-43, FET proteins and C9orf72 in the pathogenesis.  

Your tasks

The specific focus of the project will be on the identification of posttranslational modifications of TDP-43 and FET proteins and characterization of their functional consequences with respect to the normal function of these proteins and their role in the disease pathogenesis. Identified modifications will also be tested for suitability as biomarker and drug target. Primary methods will include different protein purification methods, biochemical separation techniques, mass spectrometry and cell culture.


Applicants must have a Ph.D. and should have a strong background in protein biochemistry and molecular biology. Prior experiences in protein research and biochemical analytics are highly desirable. Applicants should be fluent in English and possess good communication and team working skills.

We offer

  • Working in an international team within a stimulating research environment and with very well equipped laboratories
  • An international environment characterized by a strong focus on science and research
  • A high potential for the individual development of our employees
  • Targeted personnel development
  • Employment, payment and social benefits are determined by the Public Sector Collective Agreement (Tarifvertrag für den öffentlichen Dienst – TVöD Bund)




Contact details

Prof. Dr. Manuela Neumann

Working hours


Contract length

2 years

Payment, social benefits

according to TVöD Bund

Application deadline

January 31st, 2019

You will obtain special skills and knowledge for your scientific qualification at DZNE. The DZNE is an equal opportunity employer. It is committed to employing disabled individuals and especially encourages them to apply.