The German Center for Neurodegenerative Diseases (DZNE) is a unique non-university research center which is dedicated to the subject dementia and all its areas, as well as other neurodegenerative diseases. The center compasses the full spectrum of fundamental research through population sciences to health care research. The DZNE stands for excellence in research and science management, translation of scientific results into practice, interdisciplinarity and internationalization. It is a research center within the Helmholtz Organization of German research centers. With over 1000 employees from 55 nations, spread over 10 sites, the DZNE is one of the national and international leading research centers in its research field.
Postdoctoral Researcher (f/m/d)
The group of Dr. Daniele Bano studies the interplay between epigenetics, mitochondrial function and metabolism in aging and neurodegenerative diseases. We have described molecular regulators of mitochondrial activity that influence cellular physiology and animal survival (Gioran A. et al, 2014; Meyer K. et al, 2015; Troulinaki K. et al, 2018; Wischhof L. et al, 2018; Gioran A. et al, 2019). In collaboration with other research groups, we have provided evidence on novel mitochondria-dependent molecular cascades that control metabolic and degenerative processes (Sendoel A. et al, 2014; Sellin J. et al, 2018; Arnoux I. et al, 2018; Theurey P. et al, 2019; Cavaliere F. et al, 2019). In invertebrates as well as in higher organisms, we have investigated epigenetic factors that promote longevity and neuronal maintenance (Piazzesi A. et al, 2016; Wischhof L. et al, 2017). Additional current studies, including EU-funded transnational collaborations (e.g., ETN, IMI), focus on signaling pathways and metabolic programs that contribute to cell vulnerability due to mitochondrial lesions and aggregate-prone proteins.
We are seeking a highly motivated and science-driven postdoctoral researcher with interest in diseases associated with mitochondrial dysfunction. Starting from our previous screenings and as part of our current line of research, we wish to investigate and characterize newly identified regulators of mitochondrial bioenergetics and metabolism. As an additional goal, we will define their contribution to lifespan-extending programs and age-related degenerative processes. Projects encompass a variety of methods and approaches, including genetics, confocal laser microscopy, immunocytochemistry/ immunohistochemistry, cellular biology (e.g., mouse-derived cells and human iPSC), biochemistry and tissue preparation from transgenic mice. Previous experience with Caenorhabditis elegans is a major plus. The successful candidate is also a team player.
- An interesting and challenging task in a research center that works on the future topics of health research
- An international environment characterized by a strong focus on science and research
- A high potential for the individual development of our employees
- Targeted personnel development
- Employment, payment and social benefits are determined by the Public Sector Collective Agreement (Tarifvertrag für den öffentlichen Dienst – TVöD Bund).
Interviews will take place between October and November 2019. The position is available starting from November 2019.
Dr. Daniele Bano
Payment, social benefits
according to TVöD
You will obtain special skills and knowledge for your scientific qualification during your activities at DZNE.The DZNE is an equal opportunity employer. It is committed to employing disabled individuals and especially encourages them to apply.