The German Center for Neurodegenerative Diseases (DZNE) is a unique non-university research center which is dedicated to the subject dementia and all its areas, as well as other neurodegenerative diseases. The center compasses the full spectrum of fundamental research through population sciences to health care research. The DZNE stands for excellence in research and science management, translation of scientific results into practice, interdisciplinarity and internationalization. It is a research center within the Helmholtz Organization of German research centers. With over 1000 employees from 55 nations, spread over 10 sites, the DZNE is one of the national and international leading research centers in its research field. 

Experienced Researcher (f/m/d) Integrative Multi-omics

Code: 1715/2020/1

Population Health Sciences is one of the major scientific areas of the DZNE in Bonn, Germany. We aim to understand the complex and heterogeneous causes of neurodegenerative and other age-related diseases in order to contribute to their effective, individualized prevention and treatment. Specifically, we investigate the interplay between the genome and the exposome in determining health status. Our research is based on the Rhineland Study, a population-based cohort that will include more than 20,000 people aged 30 years and over and is designed to run for decades.

The Rhineland Study emphasizes deep phenotyping. Besides detailed clinical data we collect extensive ‘omics’ information from all our participants, including genomic, epigenomic, transcriptomic, metabolomic, proteomic as well as microbiomic data. These multi-omics data are of critical importance to most of our ongoing as well as future research projects which aim to identify and understand the molecular and biochemical pathways that mediate the effects of various risk factors on brain structure and function.

You will be responsible for the management and further development of the multi-omics platform of the Rhineland Study. You will be supported by a bioinformatician and a team of young scientists working on various aspects of the omic analyses. You will play a key role in many of the groups' research projects. In addition, you will have the opportunity to develop and lead your own research line as it fit within the general research interests of our group.  

Your tasks

  • Processing and analyzing our multi-scale omics data (including genotyping arrays, DNA/RNA sequencing and metabolomics data)
  • Supervision of graduate students
  • Analysis of data and preparation of manuscripts for publication in peer-reviewed journals
  • Maintaining contacts and active collaborations with internal and external academic and industrial partners
  • Preparation of grant applications


We are looking for a highly talented, motivated, enthusiastic and ambitious researcher with good social skills. Successful candidates have a PhD in computational biology, genomic epidemiology, biostatistics, (bio)medical sciences or a related discipline and extensive experience in bioinformatics and large-scale multi-omics projects, including genomics, epigenomics, transcriptomics or metabolomics. Demonstrated interest in quantitative research, strong analytical skills, ability for independent and critical thinking, leadership capabilities and excellent communication and writing skills in the English language are a prerequisite. 

We offer

  • Interesting and challenging work on the forefront of health research
  • Working in a highly interdisciplinary and international team
  • A high potential for the development of own research profile 
  • The position is initially for 2 years, extension possible
  • Job location is Bonn, Germany. Common language at work is English.
  • Employment, payment and social benefits are determined by the Public Sector Collective Agreement (Tarifvertrag für den öffentlichen Dienst – TVöD Bund)

The professional qualification of early career researchers is of great importance for DZNE. Besides special offers for career development and support, the DZNE also provides researchers career opportunities in form of junior research groups or internal career paths to obtain scientific independence.




Contact details

Prof. Dr. Monique Breteler

Working hours


Contract length

2 years, extension possible

Payment, social benefits

according to TVöD Bund

Application deadline

February 29th, 2020

You will obtain special skills and knowledge for your scientific qualification during your activities at DZNE. The DZNE is an equal opportunity employer. It is committed to employing disabled individuals and especially encourages them to apply.