The German Center for Neurodegenerative Diseases (DZNE) is a unique non-university research center which is dedicated to the subject dementia and all its areas, as well as other neurodegenerative diseases. The center compasses the full spectrum of fundamental research through population sciences to health care research. The DZNE stands for excellence in research and science management, translation of scientific results into practice, interdisciplinarity and internationalization. It is a research center within the Helmholtz Organization of German research centers. With over 1000 employees from 55 nations, spread over 10 sites, the DZNE is one of the national and international leading research centers in its research field. 

Postdoctoral Researcher (f/m/d)

Code: 1819/2020/6


Your tasks

The group of Dr. Daniele Bano studies the interplay between epigenetics, mitochondrial function and metabolism in aging and neurodegenerative diseases. We have described molecular regulators of mitochondrial activity that influence cellular physiology and animal survival (Gioran A. et al, 2014; Meyer K. et al, 2015; Troulinaki K. et al, 2018; Wischhof L. et al, 2018; Gioran A. et al, 2019). In collaboration with other research groups, we have provided evidence on novel mitochondria-dependent molecular cascades that control metabolism and degenerative processes (Sendoel A. et al, 2014; Sellin J. et al, 2018; Arnoux I. et al, 2018; Theurey P. et al, 2019; Cavaliere F. et al, 2019). In invertebrates as well as in higher organisms, we have investigated epigenetic factors that promote longevity and neuronal maintenance (Piazzesi A. et al, 2016; Wischhof L. et al, 2017; Piazzesi A. et al, submitted). Additional current studies, including EU-funded transnational collaborations (e.g., ETN, IMI), focus on signaling pathways and metabolic programs that contribute to cell vulnerability due to mitochondrial lesions and aggregate-prone proteins.

Requirements

We are seeking a highly motivated and science-driven postdoctoral researcher with a strong interest in mitochondria, metabolic syndromes and neurodegenerative diseases. Starting from one of our previous screenings (Bertan F. et al, in preparation) and as part of our current line of research, we wish to characterize newly identified regulators of mitochondrial bioenergetics and metabolism. In this regard, the newly advertised project will investigate novel molecular factors that contribute to the formation of mitochondrial respiratory supercomplexes (RSC). Using pharmacological and genetic approaches in mammalian cells as well as in nematodes, we will explore the mechanistic role of RSC in mitochondrial bioenergetics and metabolic reprogramming. Furthermore, we will investigate mitochondrial RSC in tissues from Alzheimer’s disease (AD) patients, correlating the presence of RSC to well-established AD hallmarks. 

The project is 1+2 years-contract, is designed on a well-established line of research (Meyer K. et al, 2015; Wischhof L. et al, 2018; Gioran A. et al, 2019; Piazzesi A. et al, submitted; Bertan F. et al, in preparation) and encompasses a variety of methods and approaches, including imaging analysis, immunocytochemistry/ immunohistochemistry, cellular biology (e.g., mouse-derived cells and human iPSC) and biochemistry. Previous experience with high-resolution confocal microscopy is an advantage. The successful candidate is also a team player.

We offer

  • An interesting and challenging task in a research center that works on the future topics of health research
  • An international environment characterized by a strong focus on science and research
  • A high potential for the individual development of our employees
  • Targeted personnel development
  • Employment, payment and social benefits are determined by the Public Sector Collective Agreement (Tarifvertrag für den öffentlichen Dienst – TVöD Bund).

 

Interviews will take place between August and October 2020. The position is available starting from November 2020.

 

Site

Bonn

Contact details

Dr. Daniele Bano

Working hours

full-time

Contract length

1 year, extension possible

Payment, social benefits

according to TVöD Bund

Application deadline

August 14th, 2020

You will obtain special skills and knowledge for your scientific qualification during your activities at DZNE. The DZNE is an equal opportunity employer. It is committed to employing disabled individuals and especially encourages them to apply.