The German Center for Neurodegenerative Diseases (DZNE) is a world-leading internationally oriented research center, committed to discovering new approaches to prevent and treat neurodegenerative diseases. To this end, researchers at ten DZNE sites across Germany pursue a translational and interdisciplinary strategy comprising five interconnected areas: fundamental research, clinical research, health care research, population health science, and systems medicine. www.dzne.de

Postdoctoral Researcher (f/m/d)

Code: 1892/2021/1


Your tasks

We are seeking highly motivated postdoctoral researchers for two vacant positions in the laboratory of Dr. Daniele Bano. Applicants will have the opportunity to choose between the following two projects:

  1. We wish to investigate the contribution of epigenetics on the “phenotypic threshold effect” of mitochondrial dysfunction. Using Caenorhabditis elegans as an in vivo model, we will explore the role of replication-independent histone variants (i.e., H3.3 and H2A.Z) in aging and longevity (Piazzesi A. et al, 2016; Piazzesi A. et al, submitted; Jackson J. et al, in preparation). Here, we will assess signaling cascades that influence survival and age-related processes of mitochondrial mutant nematodes, focusing on candidates that have been identified in our previous screens.  
  2. We wish to investigate the loss of mitochondrial respiratory supercomplexes during aging and neurodegenerative diseases. Using a recently established method (Bertan F. et al, doi: https://doi.org/10.1101/2020.12.07.414730), we will correlate mitochondrial lesions with classic disease hallmarks (e.g., tau and Ab deposition in Alzheimer’s disease; a-synuclein in Parkinson’s disease) in patient-derived samples. The project relies on imaging analysis using high-resolution confocal microscopy. Furthermore, the successful candidate will elucidate the molecular mechanisms underlying the biogenesis of mitochondrial respiratory supercomplexes, taking advantage of both in vitro and in vivo models available in the laboratory.

Requirements

The groundwork of these two projects builds on our previous cross-species studies (Meyer K. et al, 2015; Wischhof L. et al, 2017; Wischhof L. et al, 2018; Gioran A. et al, 2019; Piazzesi A. et al, submitted; Jackson J. et al, in preparation; Bertan F. et al, under revision; Wischhof L. et al, in preparation). Our laboratory employs a wide range of models (from C. elegans to transgenic mice to human iPSCs) and state-of-the-art instruments of which the successful candidates will be able to take full advantage. As such, we are searching for team players who are willing and able to employ numerous molecular techniques over the course of their projects, including genetics, microscopy, immunohistochemistry and biochemistry. Previous experience with C. elegans and/or iPSCs will help for the development of the aforementioned projects.

The two projects will develop over the initial 15-months-contract, with the concrete possibility to extend the postdoctoral experience for additional 2 years. Employees will acquire skills and knowledge for their scientific qualification during their activities at the DZNE.

Our Institute offers

  • An international environment characterized by a strong focus on science and research;
  • A high potential for targeted personnel development;
  • Employment, payment and social benefits are determined by the Public Sector Collective Agreement (Tarifvertrag für den öffentlichen Dienst – TVöD Bund).

 

 

Site

Bonn

Contact details

Dr. Daniele Bano

Working hours

full-time

Contract length

15 months, extension possible

Payment, social benefits

according to TVöD Bund

Application deadline

March 26th, 2021

The DZNE is an equal opportunity employer. It is committed to employing disabled individuals and especially encourages them to apply.