The German Center for Neurodegenerative Diseases (DZNE) is a world-leading internationally oriented research center, committed to discovering new approaches to prevent and treat neurodegenerative diseases. To this end, researchers at ten DZNE sites across Germany pursue a translational and interdisciplinary strategy comprising five interconnected areas: fundamental research, clinical research, health care research, population health science, and systems medicine. www.dzne.de

PostDoc position (f/m/d) in Experimental/Molecular Immunology

Code: 1935/2021/3

The group of Dr. Marc Beyer (DZNE Bonn site) is recruiting for a full-time postdoctoral position (39 hours per week). The position is available for an initial period of two years with possible extension. The employment is intended to start in June 2021 or upon agreement.

The main research interest of the Beyer group lies in the characterization of molecular events in innate and adaptive immune cells resulting in their activation and functional reprogramming in chronic inflammation. In the project relevant for this position, we are specifically interested in transcriptional, epigenetic and metabolic events orchestrating the programming of myeloid cells in adipose tissue in response to high caloric diet. We want to combine single-cell omics with genetic engineering as a model for the discovery and validation of cellular heterogeneity during obesity and identify key molecular drivers of the pathological process. The project is embedded in the newly established collaborative research center (CRC) 1454 “Metaflammation and Cellular Programming”.

For more general information, please also visit the website of the Beyer group

www.dzne.de/forschung/forschungsbereiche/grundlagenforschung/forschungsgruppen/beyer/forschungsschwerpunkte  


Your tasks

In this project, the successful candidate will analyze tissue from animal models as well as human patients, using a range of methodological approaches, such as single-cell RNA-sequencing, high-parameter flow cytometry, genetic engineering using CRISPR/Cas9, bioinformatics and others to determine new aspects of myeloid cell biology in adipose tissue and how this affects obesity and sterile inflammation.

Requirements

For this project, we are seeking a highly motivated, team-oriented PostDoc, with a strong interest in immunology and very good German or English proficiency.

The applicant should hold a PhD or MD/PhD degree in immunology, biochemistry, bioinformatics, molecular biology or similar topics.

The successful candidate should have prior experience either in immunobiology, molecular biology and/or high throughput sequencing techniques as well as bioinformatics.

Methodological experience in multicolor flow cytometry, transcriptomics, animal experimentation and computational biology/bioinformatics (using R or Python) is expected. Experience in single-cell omics, confocal microscopy and gene targeting is advantageous.

We expect a highly motivated and independently working candidate with a good publication track record and willingness to work in a diverse team with international scientists who is interested to participate in supervision of undergraduate and graduate students.

We offer

  • A well-funded project at the leading edge of immunology, within the emerging field of immunometabolism and immunogenomics
  • Excellent scientific infrastructure and state-of-the-art methodologies
  • An international environment characterized by a strong focus on science and research
  • A high potential for individual development of our employees (including targeted personnel development)
  • Employment, payment and social benefits are consistent with those at other research institutes

Please submit your application using the online system, consisting of your CV (incl. two references) and a brief cover letter (max. 1 page) stating your motivation for and prior experience relating to this project.

If you have further questions, please contact marc.beyer@dzne.de. Interviews will take place by video conference, with a possible on-site visit to Bonn. The position is available immediately and applications will be considered until the position is filled (with a possible starting date being June 1st, 2021).

Apply here

Site

Bonn

Contact details

Dr. Marc Beyer

Working hours

full-time

Contract length

Payment, social benefits

according to TVöD Bund

Application deadline

May 15th, 2021

You will obtain special skills and knowledge for your scientific qualification at DZNE. The DZNE is an equal opportunity employer. It is committed to employing disabled individuals and especially encourages them to apply.