The German Center for Neurodegenerative Diseases (DZNE) is a world-leading internationally oriented research center, committed to discovering new approaches to prevent and treat neurodegenerative diseases. To this end, researchers at ten DZNE sites across Germany pursue a translational and interdisciplinary strategy comprising five interconnected areas: fundamental research, clinical research, health care research, population health science, and systems medicine. www.dzne.de

Postdoc (m/f/x) in Experimental/Molecular Neuroimmunology

Code: 3062/2021/7

The groups of Dr. Jonas Neher (DZNE Tübingen site, where the position will be located) and Dr. Marc Beyer (DZNE Bonn site) have a joint interest in how peripheral inflammation affects the immune response of the brain. In this project funded through the Else Kröner-Fresenius-Stiftung, the two groups will be jointly investigating how peripheral inflammation alters the microglial phenotype in the short and long-term, both in mouse models as well as human tissue. In particular, this project aims to define the molecular underpinnings of innate immune memory in microglia (as shown by their groups for the first time in Wendeln et al., Nature, 2018) and will take these analyses to the next level by combining state-of-the-art single cell RNA-sequencing as well as epigenetic profiling of microglial cells. We will also test how different peripheral immune stimuli affect the pathology of Alzheimer’s disease, generating a comprehensive map of the molecular alterations that define innate immune memory in microglia and how they may alter neurodegenerative disease, while also examining the molecular effects on other major cell types of the brain.

For more general information, please also visit the websites of the Neher and Beyer groups:www.dzne.de/neher

www.dzne.de/forschung/forschungsbereiche/grundlagenforschung/forschungsgruppen/beyer/forschungsschwerpunkte 


Your tasks

As part of a larger project team, the successful candidate will analyse tissue from animal models as well as human patients, using a range of methodological approaches, such as single nucleus RNA-sequencing, histology, biochemistry, bioinformatics etc. to determine what defines immune memory in microglia and how this affects neurodegeneration.

Requirements

For this 2-year project, we are seeking a highly motivated postdoc, with a strong interest in neuroimmunology and very good German or English proficiency.

For this position, the successful candidate should have prior experience in at least two of the following scientific fields:

  • Animal models of inflammation and/or Alzheimer’s disease (incl. FELASA certificate or equivalent)
  • High-throughput sequencing methods
  • Bioinformatics analyses

The successful postdoctoral researcher will also assist with coordinating the project and should therefore demonstrate excellent communication, team-work and fundamental leadership skills. The successful candidate will of course be able to acquire additional methods during the course of this project.

We offer

  • A well-funded project at the leading edge of (neuro-)immunology, within the emerging field of innate immune memory
  • Excellent scientific infrastructure and state-of-the-art methodologies
  • An international environment characterized by a strong focus on science and research
  • A high potential for individual development of our employees (including targeted personnel development)
  • A full-time position, initially temporary limited to 2 years, with possible extension
  • Employment, payment and social benefits determined by the Public Sector Collective Agreement (Tarifvertrag für den öffentlichen Dienst – TVöD Bund)

Please submit your application using the online system, consisting of your CV (incl. peer-reviewed publications and identifying two references) and a brief cover letter (max. 1 page) stating your motivation for and prior experience relating to this project. If you have further questions, please contact jonas.neher@dzne.de. Interviews will take place by video conference, with a possible onsite visit to Tübingen. Applications will be considered until the position is filled (with the latest possible starting date being December 1st, 2021).

Apply here

Site

Tübingen

Contact details

jonas.neher@dzne.de

Working hours

full-time

Contract length

2 years, extension possible

Payment, social benefits

according to TVöD Bund

Application deadline

01.09.2021

You will obtain special skills and knowledge for your scientific qualification during your activities at DZNE. The DZNE is an equal opportunity employer. It is committed to employing disabled individuals and especially encourages them to apply.